PMID: 528375Oct 1, 1979Paper

Synthesis and antibacterial activity of 1-N-(1,3-dihydroxy-2-propyl)kanamycin B (UK-31,214)

The Journal of Antibiotics
K RichardsonJ R Wright

Abstract

1-N-(1,3-Dihydroxy-2-propyl)kanamycin B was prepared and its in vitro activity against aminoglycoside-sensitive and aminoglycoside-resistant organisms was compared with that of kanamycin B and gentamicin. This kanamycin B derivative (code No. UK-31,214) demonstrated potent activity in all of these tests and gave good protection in experimental infections in mice.

Related Concepts

Aminoglycosides
Bacterial Infections
Antibiotic Resistance, Microbial
Kantrex
Fungus Drug Sensitivity Tests

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