Synthesis and antibacterial activity of new fluoroquinolones containing a substituted N-(phenethyl)piperazine moiety

Bioorganic & Medicinal Chemistry Letters
Alireza ForoumadiAbbas Shafiee

Abstract

N-(Phenethyl)piperazinyl quinolone derivatives that bear a methoxyimino-substituent have been synthesized and evaluated for antimicrobial activity against Gram-positive and Gram-negative microorganisms. In addition, to define structure-activity relationships, ciprofloxacin derivatives containing 2-oxo-2-phenylethyl or 2-hydroxyimino-2-phenylethyl moieties at N-4 position of piperazine ring were prepared and tested. Ciprofloxacin derivatives, containing a N-(chloro-substituted phenethyl) residue, showed in vitro Gram-positive and Gram-negative activity generally comparable or superior to that of reference quinolones.

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Citations

Dec 31, 2010·Archives of Pharmacal Research·M Saeed ArayneSyeda Bushra Shakeb Rizvi
Jan 29, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Negar MohammadhosseiniAlireza Foroumadi
Oct 11, 2011·Journal of Enzyme Inhibition and Medicinal Chemistry·Prabodh Chander SharmaHarish Rajak
Feb 11, 2014·Journal of Enzyme Inhibition and Medicinal Chemistry·Łukasz PopiołekAnna Malm
Jan 5, 2013·European Journal of Medicinal Chemistry·Tomasz PlechMałgorzata Polz-Dacewicz
Apr 11, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomasz PlechMałgorzata Polz-Dacewicz
Mar 20, 2010·Journal of Enzyme Inhibition and Medicinal Chemistry·Prabodh Chander SharmaMohammad Shahar Yar
Jul 9, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·C S Ananda KumarK S Rangappa
Oct 5, 2019·Future Medicinal Chemistry·Beatriz Suay-GarcíaGerardo M Antón-Fos
Jan 9, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Rishi Kant, Suman Maji
Jun 3, 2021·International Journal of Molecular Sciences·Jose I Bueso-BordilsGerardo M Antón-Fos

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