PMID: 11902647Mar 21, 2002Paper

Synthesis and antibacterial activity of pyridazino[4,3-b]indole-4-carboxylic acids carrying different substituents at N-2

Il Farmaco
F PalluottoCesare Vitali

Abstract

The synthesis and the in vitro evaluation of antibacterial activity of new pyridazino[4,3-b]indole-4-carboxylic acids 2-4, 6 against some selected representative of Gram-positive and Gram-negative bacteria are reported. The role of the lipophilicity in the modulation of the antibacterial activity of the tested compounds is discussed. All the synthesized compounds appear quite weak against Gram-positive bacteria, whereas have no significant activity against Gram-negative bacteria. Only derivative 2g possesses an interesting activity against Gram-positive bacteria.

References

Dec 1, 1993·Bioorganic & Medicinal Chemistry·F CampagnaG B De Sarro
Jan 1, 1999·Bioorganic & Medicinal Chemistry Letters·B B LohrayH M Sarnaik

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Citations

Aug 29, 2007·Analytica Chimica Acta·Victor C DiculescuAna Maria Oliveira-Brett
Dec 15, 2010·European Journal of Medicinal Chemistry·Francesco CampagnaGerardo Palazzo
Oct 28, 2017·Journal of Chemical Biology·Hau-Heredia LeninEuan-Hau Saidy

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