Synthesis and antibacterial evaluation of oxazolidin-2-ones structurally related to linezolid

Il Farmaco
Alessandra AmmazzalorsoMaria L Tricca

Abstract

Compounds structurally related to the known antimicrobial drug linezolid were selected in order to evaluate the influence of electron-withdrawing properties and altered geometric features as a result of the N-substituent modification. After a preliminary study of molecular modeling, cinnamoyl-, pyridin- and pyrimidinoxazolidin-2-ones were synthesized. None of the new compounds showed antibacterial activity.

References

May 1, 1997·Trends in Microbiology·C W FordG E Zurenko
Mar 16, 2000·Drugs·D I Diekema, R N Jones

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Citations

May 3, 2005·Bioorganic & Medicinal Chemistry Letters·Rosa GrieraJoan Huguet
Dec 13, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pavlina MarvanovaPetr Mokry
Jun 4, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pavlina MarvanovaJosef Jampilek

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