PMID: 8942057May 1, 1996Paper

Synthesis and antibacterial testing of some new quinolines, pyridazinoquinolines and spiroindoloquinolines

Bollettino chimico farmaceutico
A A el-AhlM A Metwally

Abstract

3-Dicyanomethylideneindole derivatives were involved in (i) ring expansion reactions in alcoholic piperidine to form new quinolines from which a new pyridazinoquinoline was synthesised; and (ii) formation of new spiroindoloquinolines by reactions with cyclohexanone and beta-tetralone. The suggested structures of the new products were confirmed by IR, 1H-NMR, 13C-NMR and mass spectral analyses. Some of the new derivatives were active against the bacteria Escherichia cell.

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