Synthesis and Anticancer Activity of New ((Furan-2-yl)-1,3,4-thiadiazolyl)-1,3,4-oxadiazole Acyclic Sugar Derivatives

Chemical & Pharmaceutical Bulletin
Asmaa F KassemWael A El-Sayed

Abstract

New sugar hydrazones incorporating furan and/or 1,3,4-thiadiazole ring systems were synthesized by reaction of the corresponding hydrazide with different aldose sugars. Heterocyclization of the formed hydrazones afforded the derived acyclic nucleoside analogues possessing the 1,3,4-oxadiazoline as modified nucleobase via acetylation followed by the heterocyclization process. The anticancer activity of the synthesized compounds was studied against human liver carcinoma cell (HepG-2) and at human normal retina pigmented epithelium cells (RPE-1). High activities were revealed by compounds 3, 12 and 14 with IC50 values near to that of the reference drug doxorubicin.

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Citations

Jan 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ebtesam A BasionyWael A El-Sayed
Dec 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hatem A AbuelizzRashad Al-Salahi
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Adel A-H Abdel-RahmanWael A El-Sayed

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