PMID: 11900869Mar 20, 2002Paper

Synthesis and anticancer and anti-HIV testing of some pyrazino[1,2-a]benzimidazole derivatives

European Journal of Medicinal Chemistry
Seref DemirayakAhmet Cağri Karaburun

Abstract

In this study, some 1-methylene-2,3-diaryl-1,2-dihydropyrazino[1,2-a]benzimidazole and some 1-(2-arylvinyl)-3-arylpyrazino[1,2-a]benzimidazole derivatives were synthesised. The structure elucidation of the compounds was performed by IR, 1H-NMR and MASS spectroscopic data and elemental analyses results. Anticancer and anti-HIV activities of the compounds were examined, however no anti-HIV activity was seen; highly notable anticancer activity was obtained. It was also observed that the compounds were more potent against leukaemia cell lines.

References

Aug 1, 1975·Journal of Medicinal Chemistry·K H LeeE S Huang
Jul 1, 1989·Journal of Medicinal Chemistry·E O OrlemansM C Bibby
Dec 1, 1972·Journal of Medicinal Chemistry·A J LinA C Sartorelli
Dec 1, 1971·Journal of Medicinal Chemistry·S M KupchanA M Thomas
Oct 1, 1981·Journal of Medicinal Chemistry·J C HodgesW T Bradner
Aug 1, 1981·Journal of Medicinal Chemistry·B S IyengarW T Bradner
Apr 1, 1994·Journal of Pharmaceutical Sciences·E ErciyasG Cosar
Aug 28, 1999·Journal of Medicinal Chemistry·W A CraigoE B Skibo
May 2, 1997·The Journal of Organic Chemistry·Steven E. RokitaWilliam A. Greenberg
Feb 19, 2002·Chemical Reviews·Scott R. Rajski, Robert M. Williams

❮ Previous
Next ❯

Citations

Jan 22, 2013·European Journal of Medicinal Chemistry·Asif HusainRavinesh Mishra
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Naser Eltaher EltayebRohana Adnan
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Li-Jing CuiKe-Ji Pan
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Naser Eltaher EltayebRohana Adnan
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Naser Eltaher EltayebSuchada Chantrapromma
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Fang-Ming Wang
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Natarajan ArumugamHoong-Kun Fun
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Naser Eltaher EltayebSuchada Chantrapromma
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Zishan TabassumHoong-Kun Fun
Nov 8, 2011·Acta Crystallographica. Section E, Structure Reports Online·Naser Eltaher EltayebHoong-Kun Fun
Nov 8, 2011·Acta Crystallographica. Section E, Structure Reports Online·Naser Eltaher EltayebKong Mun Lo
Jan 20, 2012·Acta Crystallographica. Section E, Structure Reports Online·Yeong Keng YoonIbrahim Abdul Razak
Feb 22, 2012·Acta Crystallographica. Section E, Structure Reports Online·Yeong Keng YoonIbrahim Abdul Razak
Jun 22, 2012·Acta Crystallographica. Section E, Structure Reports Online·Yeong Keng YoonIbrahim Abdul Razak
Feb 21, 2013·Acta Crystallographica. Section E, Structure Reports Online·T MohandasP Sakthivel
Apr 3, 2012·Chemical & Pharmaceutical Bulletin·Venkatapuram PadmavathiAdivireddy Padmaja
Apr 17, 2014·European Journal of Medicinal Chemistry·Veerendra Kumar A KalalbandiKishore G Bhat
Jan 25, 2014·Journal of Enzyme Inhibition and Medicinal Chemistry·Şeref Demirayak, Leyla Yurttaş
Jun 9, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abdulrahman I AlmansourHazem A Ghabbour
Oct 26, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marijana Hranjec, Grace Karminski-Zamola
Feb 24, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yahia Nasser MabkhotTaibi Ben Hadda
Jan 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmet Çağrı KaraburunZafer Asım Kaplancıklı
Aug 7, 2019·BMC Chemistry·Sumit TahlanBalasubramanian Narasimhan
May 18, 2012·Archiv der Pharmazie·Venkatapuram PadmavathiAdivireddy Padmaja
Nov 2, 2017·Mini Reviews in Medicinal Chemistry·Yogita BansalGulshan Bansal
Dec 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marina PorchiaCarlo Santini
Mar 1, 2012·European Journal of Medicinal Chemistry·Ahmed KamalShasi V Kalivendi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Related Papers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
N S PawarP P Mahulikar
Bioorganic & Medicinal Chemistry
Kristina StarcevićGrace Karminski-Zamola
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Sven GrassmannWalter Schunack
Acta Crystallographica. Section E, Structure Reports Online
Yeong Keng YoonIbrahim Abdul Razak
© 2022 Meta ULC. All rights reserved