Synthesis and antifungal activities of novel nicotinamide derivatives containing 1,3,4-oxadiazole

Chemistry Central Journal
Jian WuSong Yang

Abstract

Pant diseases in agriculture are extremely difficult to control, which bring about for billions of dollars in economic losses worldwide each year; Nicotinamide derivatives has attracted more and more attention in the field of pesticide due to their broad bioactivities. In an effort to discover new molecules with good antifungal activity, a series of nicotinamide derivatives containing 1,3,4-oxadiazole were synthesized and bio-assayed. Bioassays demonstrated that some of the title compounds exhibited favorable antifungal activities against Gibberella zeae, Fusarium oxysporum, and Cytospora mandshurica. compounds 7b, 7c, 8, 9a, 9b, and 9c displayed 46.4%, 39.6%, 53.0%, 43.2%, 58.3%, 45.6% activities against G. Zeae, respectively; the activities of compounds 7a, 7b, 8, 9a, 9b, and 9c against F. oxysporum were 55.2%, 51.1%, 58.9%, 63.2%, 53.3%, and 47.6%, respectively; whereas inhibitory rates of compounds 7a, 7b, 7c, 8, 9a, 9b, and 9c on C. mandshurica were 53.1%, 49.9%, 44.9%, 52.8%, 59.8%, 54.5%, and 49.3%, respectively. A series of the novel nicotinamide derivatives containing 1,3,4-oxadiazole were synthesized and bio-assayed. The results of antifungal tests revealed that the synthesized nicotinamide derivatives possessed weakl...Continue Reading

References

Sep 16, 1994·Journal of Medicinal Chemistry·S W WrightJ V Giannaras
Jul 31, 2004·Annual Review of Phytopathology·Guihua Bai, Gregory Shaner
Jan 22, 2008·Bioorganic & Medicinal Chemistry·David A ClarkDon G Clagg
Nov 3, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Weiming XuMaoguo Tong
Jan 3, 2012·Journal of Agricultural and Food Chemistry·Wei-Ming XuBao-An Song

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Citations

Feb 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hamada Mohamed Ibrahim, Haider Behbehani
Jul 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zaibo YangXiuhai Gan
Mar 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tamara SiberDajana Gašo-Sokač
Oct 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zai-Bo YangYin-Ju He

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Methods Mentioned

BETA
infrared spectroscopy

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