Synthesis and antifungal activity of the derivatives of novel pyrazole carboxamide and isoxazolol pyrazole carboxylate

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jialong Sun, Yuanming Zhou

Abstract

A series of pyrazole carboxamide and isoxazolol pyrazole carboxylate derivatives were designed and synthesized in this study. The structures of the compounds were elucidated based on spectral data (infrared, proton nuclear magnetic resonance and mass spectroscopy). Then, all of the compounds were bioassayed in vitro against four types of phytopathogenic fungi (Alternaria porri, Marssonina coronaria, Cercospora petroselini and Rhizoctonia solani) using the mycelium growth inhibition method. The results showed that some of the synthesized pyrazole carboxamides displayed notable antifungal activity. The isoxazole pyrazole carboxylate 7ai exhibited significant antifungal activity against R. solani, with an EC50 value of 0.37 μg/mL. Nonetheless, this value was lower than that of the commercial fungicide, carbendazol.

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Citations

Jun 14, 2017·Journal of Peptide Science : an Official Publication of the European Peptide Society·Anna Kusakiewicz-DawidDawid Siodłak
Jan 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Khalid KarrouchiM'hammed Ansar
Jun 1, 2018·Acta Crystallographica. Section E, Crystallographic Communications·Abdullah AydinErden Banoğlu
Jul 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zaibo YangXiuhai Gan
May 12, 2020·Bioorganic & Medicinal Chemistry Letters·Shaoyong KeDaye Huang

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Methods Mentioned

BETA
nuclear magnetic resonance

Software Mentioned

SPSS

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Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.