PMID: 9544941Apr 17, 1998Paper

Synthesis and antimicrobial evaluation of TAN-1057A/B analogs

The Journal of Antibiotics
R M WilliamsS Chamberland

Abstract

TAN-1057A-D, dipeptides isolated from bacteria Flexibacter sp. PK-74 and PK-176, are new antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). We describe, in detail, the synthesis of several TAN-1057A/B analogs by a convergent route featuring a new method to construct the cyclic amidinourea functional group. The biological activity of these substances against methicillin-resistant Staphylococcus aureus (MRSA) is reported.

Citations

Jan 27, 2004·Antimicrobial Agents and Chemotherapy·E LimburgD Beyer
Jan 26, 2008·Organic & Biomolecular Chemistry·Mathieu Pucheault
Aug 2, 2006·Angewandte Chemie·Franz von NussbaumDieter Häbich
Jan 17, 2020·The Journal of Antimicrobial Chemotherapy·W Scott Champney
Aug 19, 2005·Expert Review of Anti-infective Therapy·André Bryskier
Jun 22, 2021·Accounts of Chemical Research·Matthew R NelliRyan E Looper
Mar 13, 2018·Bioconjugate Chemistry·Md Salauddin AhmedJoong Ho Moon

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