Synthesis and antimicrobial studies of a new series of 2-[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]-5-substituted-1,3,4-oxadiazoles

European Journal of Medicinal Chemistry
S L GaonkarB Prabhuswamy

Abstract

A series of novel 2-[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]-5-substituted-1,3,4-oxadiazoles were synthesized by the oxidative cyclisation of hydrazones derived from 4-[2-(5-ethylpyridin-2-yl)ethoxy]benzaldehyde and aroylhydrazines using chloramine-T as oxidant. IR, NMR and elemental analysis characterized the newly synthesized compounds. The synthesized compounds were evaluated for their antimicrobial activity and were compared with standard drugs. The compounds demonstrated potent to weak antimicrobial activity. Out of the compounds studied, compounds 8c and 8d showed significant inhibition. Compounds 8b, 8f, 8k and 8e showed moderate activity. The minimum inhibitory concentration of the compounds was in the range of 8-26 microg ml(-1) against bacteria and 8-24 microg ml(-1) against fungi. The title compounds represent a novel class of potent antimicrobial agents.

Citations

Feb 24, 2010·Indian Journal of Pharmaceutical Sciences·A Husain Sarafroz
Jan 17, 2012·Organic & Biomolecular Chemistry·Manishkumar B PatelShobhana K Menon
Jun 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abd El-Galil E AmrElsayed A Elsayed
Dec 29, 2020·Bioorganic & Medicinal Chemistry·Valentin KarabelyovViolina T Angelova
Jan 12, 2021·Frontiers in Chemistry·Gabriela A FernándezLucia V Cavallaro

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