Dec 25, 2007

Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs--Part II

Steroids
Pemmaraju N RaoJamshed Shah

Abstract

The syntheses and antimitotic activity of several novel 18a-homo-analogs of 2-methoxyestradiol are described. Structural modifications of the parent 2-methoxy-18a-homoestradiol include introduction of unsaturation in the D-ring and methylation of the 17-OH. Of seven analogs synthesized, one has demonstrated superior biological activities compared to 2-methoxyestradiol. The relationship between biological activity and the conformational preference of the 13-ethyl group as determined by computational analysis is discussed.

Mentioned in this Paper

Trientine
Metabolic Process, Cellular
Diazomethane
Ethanol
Pyridines
Derivatives
Ethanol Measurement
Ethylene Glycol Measurement
Protein Methylation
Sodium sulfate

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