PMID: 11902649Mar 21, 2002Paper

Synthesis and antimycobacterial activity of 3-aryl-, 3-cyclohexyl- and 3-heteroaryl- substituted-2-(1H(2H)-benzotriazol-1(2)-yl)prop-2-enenitriles, prop-2-enamides and propenoic acids. II

Il Farmaco
P SannaRahbar Nikookar

Abstract

A series of 32 3-aryl-, 3-cyclohexyl-, and 3-heteroaryl-substituted-2-(1H(2H)-benzotriazol-1(2)-yl)-prop-2-enenitriles, prop-2-enamides and propenoic acids, was synthesized as a part of our research in the antitubercular field, according to an international program with the Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF). This work reports the preparation and analytical and spectroscopic characterization (MS, UV, IR, 1H NMR) of all compounds synthesized. Among these only a few compounds (E-4b,c, E-5a, E-7e and E-8d) were found to be endowed with modest growth inhibition of Mycobacterium tuberculosis. However, the obtained results allowed to acquire interesting structure-activity relationships.

References

Jan 18, 1995·JAMA : the Journal of the American Medical Association·M C RaviglioneA Kochi
Feb 25, 1993·The New England Journal of Medicine·T R FriedenS W Dooley

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Citations

Sep 25, 2004·Medicinal Research Reviews·Rama P TripathiVinod K Tiwari
Oct 12, 2013·European Journal of Medicinal Chemistry·Mohammad Sayed AlamDong-Ung Lee
Nov 26, 2002·European Journal of Medicinal Chemistry·Antonio CartaRoberta Loddo
Mar 24, 2011·Future Medicinal Chemistry·Prem M S ChauhanMoni Sharma
Jul 12, 2011·European Journal of Medicinal Chemistry·Antonio CartaSabrina Pricl
Oct 9, 2014·European Journal of Medicinal Chemistry·I BriguglioA Carta
Jun 5, 2004·Il Farmaco·Gianluca SbardellaPaolo La Colla
Dec 15, 2010·European Journal of Medicinal Chemistry·Antonio CartaStefania Zanetti
Jun 11, 2004·Journal of Medicinal Chemistry·Franciszek SaczewskiPatrick J Bednarski

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