Synthesis and antimycobacterial activity of new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives

European Journal of Medicinal Chemistry
Elsa MorenoAntonio Monge

Abstract

As a continuation of our research and with the aim of obtaining new anti-tuberculosis agents which can improve the current chemotherapeutic anti-tuberculosis treatments, forty-three new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives were synthesized and evaluated for in vitro anti-tuberculosis activity against Mycobacterium tuberculosis strain H(37)Rv. Active compounds were also screened to assess toxicity to a VERO cell line. Results indicate that compounds with a methyl moiety substituted in position 3 and unsubstituted benzyl substituted on the carboxamide group provide an efficient approach for further development of anti-tuberculosis agents.

Citations

Jul 3, 2013·European Journal of Medicinal Chemistry·Enrique TorresSilvia Pérez-Silanes
Jan 26, 2013·Chemical Reviews·Bagher Eftekhari-SisAli Akbari
Feb 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Awwad A Radwan, Wael M Abdel-Mageed
Feb 21, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana GilIgnacio Aldana
Aug 15, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zuzana BarbierikováVlasta Brezová
Apr 24, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carlos BareaIgnacio Aldana
Jan 12, 2016·Bioorganic & Medicinal Chemistry Letters·Silvia Pérez-SilanesElsa Moreno-Viguri
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Mar 24, 2016·Antimicrobial Agents and Chemotherapy·Vanessa KaplumCelso Vataru Nakamura

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