Synthesis and antimycobacterial activity of novel 1,3-dimethylisocyanurate derivatives

European Journal of Medicinal Chemistry
M M ShulaevaV S Reznik

Abstract

A series of novel 1,3-dimethylisocyanurates has been synthesized as potential inhibitors of β-ketoacyl synthase in mycobacteria. Most of the 25 compounds described and tested for their activity against M. tuberculosis have a bacteriostatic effect, comparable and even higher that of first-line antituberculosis drugs. These compounds are nontoxic, species-specific, exhibiting no activity against other bacterial species.

References

Sep 1, 2000·Journal of Medicinal Chemistry·P B JonesC A Townsend
Apr 18, 2002·Current Drug Targets·Ying Zhang, L Mario Amzel
Aug 8, 2002·Current Pharmaceutical Biotechnology·E K SchroederL A Basso
Sep 10, 2004·The Journal of Antimicrobial Chemotherapy·Nicole M ParrishJames D Dick
Feb 13, 2007·Bioorganic & Medicinal Chemistry·Yves L Janin
Jun 27, 2008·Bioorganic & Medicinal Chemistry Letters·Samir GhoshSudhir Sinha
Jun 13, 2009·Tuberculosis·Nicole M ParrishJames D Dick

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Citations

Jun 1, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·A NiewiadomyG Macik-Niewiadomy
Mar 23, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·J MatysiakG Macik-Niewiadomy

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