Synthesis and antioxidant activity of bis and tris heterocycles

Archiv der Pharmazie
Nabhubygari Mahaboob BashaTartte Vijaya

Abstract

A variety of bis heterocycles, oxazolyl/thiazolyl/imidazolyl oxadiazoles having a styryl sulfonylmethyl group at the 5-position of oxadiazole and tris heterocycles having a pyrrolyl/pyrazolyl sulfonylmethyl group at the 5-position of oxadiazole were prepared adopting simple and versatile synthetic methodologies. All the compounds were screened for their antioxidant activities. Compound 5b displayed radical scavenging activity in all the three methods greater than the standard ascorbic acid, whereas compounds 8b and 14b showed activities equal to the standard ascorbic acid.

References

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Citations

Oct 17, 2018·Mini Reviews in Medicinal Chemistry·Garima VermaMohammad Shaquiquzzaman

Related Concepts

2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid, diammonium salt
Alpha, alpha-diphenyl-beta-picrylhydrazyl
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Biphenyl Compounds
Heterocyclic Compounds
Nitric Oxide
Picrates
Structure-Activity Relationship
Sulfonic Acids
Drug Modeling

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