Synthesis and antiplasmodial activity of lycorine derivatives

Bioorganic & Medicinal Chemistry
Juan C CedrónAna Estévez-Braun

Abstract

Twenty seven lycorine derivatives were prepared and evaluated for their in vitro antimalarial activity against chloroquine-sensitive strains of Plasmodium falciparum. The best antiplasmodial activities were achieved with lycorine derivatives that present free hydroxyl groups at C-1 and C-2 or esterified as acetates or isobutyrates. The double bond C-2-C-3 is also important for the activity. Concerning to the antiplasmodial activity of the secolycorines, the higher values were obtained with the replacement of the methylenedioxy moiety by hydroxyl or acetate groups and with methyl substituent attached to the nitrogen atom.

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Citations

Apr 27, 2011·Journal of Agricultural and Food Chemistry·Cheng-Xia TanAgnes M Rimando
Aug 13, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juan C CedrónAna Estévez-Braun
Jan 21, 2012·Chemical Biology & Drug Design·Raquel B GiordaniMauro V de Almeida
Nov 26, 2015·Antimicrobial Agents and Chemotherapy·Yu GuoYuna Sun
Nov 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lucie CahlíkováLubomír Opletal
Dec 16, 2017·Archives of Pharmacal Research·Marcela ŠafratováLucie Cahlíková
Apr 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eliška KohelováLucie Cahlíková
Jun 12, 2020·Parasitology Research·Brenda Petró-SilveiraTiana Tasca
Jan 1, 2013·Science China. Chemistry·ZhiFei CaoQuanSheng Zhou
May 7, 2013·Natural Product Reports·Zhong Jin
Nov 1, 2020·Journal of Experimental & Clinical Cancer Research : CR·Chongyang LiHongjuan Cui
Feb 22, 2021·The Journal of Biological Chemistry·Anutthaman ParthasarathyAndré O Hudson
Mar 9, 2021·Frontiers in Pharmacology·Chee Kei KongPoh Hui Goh
Aug 17, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mridul RoyJing Liu
Aug 15, 2021·Parasitology International·Shengwei JiXuenan Xuan

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