Synthesis and antithrombogenicity of polyetherurethaneurea containing quaternary ammonium groups in the side chains and of the polymer/heparin complex

Journal of Biomedical Materials Research
Y ItoY Imanishi

Abstract

Novel polyetherurethaneureas containing tertiary amino groups in the side chains (PAEUU) were synthesized, quaternized with different alkyl halides (Q-PAEUU), and heparinized (H-PAEUU). The antithrombogenicity of PAEUU in vitro was improved by quaternization, and further by heparinization. The excellent antithrombogenicity of H-PAEUU was controlled by the kind of quaternizing agent through the polar effect of quaternizing agent on the water content and through the steric effect of quaternizing agent on the heparin content of H-PAEUU. The antithrombogenicity of H-PAEUU was found to be affected by the water content more strongly than by the heparin content. H-PAEUUs containing tertiary amino groups in the main chain, which were synthesized previously, showed a little better short-term antithrombogenicity than the present H-PAEUUs containing tertiary amino groups in the side chains. Since ammonium groups in the side chains of Q-PAEUU impose little steric hindrance against the heparin adsorption, the release of heparin from the side chains of H-PAEUU was slower but lasted longer than that from the main chain. Therefore, the present H-PAEUU is expected to be a long-term antithrombogenic material.

References

Mar 1, 1977·Journal of Biomedical Materials Research·H MiyamaH Tanzawa
Apr 1, 1985·Journal of Biomedical Materials Research·P W HeymanS W Kim
Jan 1, 1973·Transactions - American Society for Artificial Internal Organs·H TanzawaM Hori
Sep 1, 1973·Journal of Biomedical Materials Research·S D Bruck
May 1, 1972·Journal of Biomedical Materials Research·Y Imai, Y Nose
Sep 1, 1970·Journal of Biomedical Materials Research·D W MarshallH J Bixler
May 1, 1983·Journal of Biomedical Materials Research·D Basmadjian, M V Sefton
Dec 1, 1980·Thrombosis Research·M F GoosenM W Hatton

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Citations

Nov 1, 1991·Journal of Biomedical Materials Research·Y ItoY Imanishi
Jun 1, 2000·Journal of Inorganic Biochemistry·Y Ito
Jul 21, 2000·Journal of Biomaterials Science. Polymer Edition·P PetriniP Speziale
Jan 1, 1993·Journal of Biomaterials Science. Polymer Edition·T KashiwagiY Imanishi
Jan 1, 1994·Journal of Biomaterials Science. Polymer Edition·Y ItoY Imanishi
Jun 29, 1999·Journal of Biomaterials Science. Polymer Edition·R G FlemmingS L Cooper
Jul 2, 2008·Chemical & Pharmaceutical Bulletin·Shin-Ichi KondoMasayuki Kuzuya
Apr 1, 1988·Journal of Biomaterials Applications·R EloyJ Baguet
Oct 1, 1987·Journal of Biomaterials Applications·Y Ito
Apr 1, 1992·Journal of Biomaterials Applications·Y Ito, Y Imanishi
Oct 1, 1986·Journal of Biomedical Materials Research·Y ItoY Imanishi
Jul 18, 2002·The Journal of Surgical Research·Jian-ming LiBruce S Cutler

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