Synthesis and antitumor activities of transition metal complexes of a bis-Schiff base of 2-hydroxy-1-naphthalenecarboxaldehyde.

Journal of Inorganic Biochemistry
Shaozhan ShiFupei Liang

Abstract

The complexes of Schiff base have attracted much attention for their potential biological activities. In this research, five transition metal complexes TM3L2(OAc)2 (TM = Cu, 1; Ni, 2; Co, 3; Mn, 4; Fe, 5) were prepared using a bis-Schiff base of N,N'-bis[(2-hydroxy-1-naphthalenyl)methylene]-propane-1,3-diamine (H2L), which present similar linear trinuclear structures with their three metal ions consolidated by two bis-Schiff base ligands and two acetate ligands. Their antitumor activities in vitro were screened through seven human cancer cell lines by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. It revealed that complexes 1, 2 and 5 show much higher antitumor activities than the bis-Schiff base ligand and complexes 3 and 4, and even than cisplatin. Among them, complex 1 has the highest inhibitory effects on tumor cells with its IC50 value (half-inhibitory concentration) being less than 0.5 μM for human bladder cancer cell line T-24, at which concentration complex 1 shows nearly no toxicity to the normal cell HL-7702 as revealed by flow cytometry. All of these demonstrate a potential anti-cancer candidate for complex 1, which induces tumor cell apoptosis by blocking T-24 tumor cells at the G2/M p...Continue Reading

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