Synthesis and antiviral activity of P1' arylsulfonamide azacyclic urea HIV protease inhibitors

Bioorganic & Medicinal Chemistry Letters
Peggy P HuangD J Kempf

Abstract

A series of novel azacyclic urea HIV protease inhibitors bearing a benzenesulfonamide group at P1' were synthesized utilizing a parallel synthesis method. Structural studies of early analogs bound in the enzyme active site were used to design more potent inhibitors. The effects of substituting the P1' benzenesulfonyl group on antiviral activity and protein binding are described.

References

Jun 15, 2004·Current Topics in Medicinal Chemistry·John T Randolph, David A DeGoey

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Citations

Jan 22, 2013·Artificial Cells, Nanomedicine, and Biotechnology·Nahit GençerMustafa Küçükislamoğlu
May 9, 2021·Bioorganic Chemistry·Farid M SroorMostafa E El-Naggar

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