Synthesis and Antiviral Activity of Water-Soluble Polycarboxylic Derivatives of [60]Fullerene Loaded with 3,4-Dichlorophenyl Units

Chemistry & Biodiversity
Ilya I VoronovPavel A Troshin

Abstract

We have synthesized a series of water-soluble polycarboxylic derivatives of [60]fullerene with a gradually changed polarity by combining three to five polar (ionic) malonate addends with two to zero hydrophobic dichlorobenzene units and explored their antiviral activity. It has been shown that decreasing the number of the ionogenic carboxylic groups in the molecules enhanced their antiviral activity against HIV-1 and suppressed their action against HIV-2. The obtained results implied that the charged states and hydrophobicity of the water-soluble polycarboxylic fullerene derivatives affect significantly their biological properties.

References

Dec 14, 2006·Organic & Biomolecular Chemistry·David L WallerPeter Wipf
Oct 7, 2009·Nanotechnology·Daniel Loss
Oct 21, 2011·Chemical Communications : Chem Comm·Jianhua Cheng, Zhaomin Hou
Oct 10, 2015·The Journal of Chemical Physics·Kyle J MascaritoloMichael C Heaven

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Citations

Aug 5, 2020·Chemical Communications : Chem Comm·Olga A KraevayaPavel A Troshin
Aug 5, 2020·Drug Delivery and Translational Research·Malobika Chakravarty, Amisha Vora

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