Synthesis and antiviral evaluation of novel open-chain analogues of neplanocin A

Nucleosides, Nucleotides & Nucleic Acids
Joon Hee HongJung-Hyuck Cho

Abstract

Novel acyclic nucleoside analogues were designed and synthesized as open-chain analogues of neplanocin A. The coupling of the allylic bromide with purine bases using cesium carbonate afforded a series of novel acyclic nucleosides. The synthesized compounds Ia-II were evaluated for their antiviral activity against various viruses such as HIV HSV-1, HSV-2, and ECMV.

Citations

Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Venkat S R K Yedavalli, Kuan-Teh Jeang
Mar 2, 2011·RNA Biology·Venkat S R K Yedavalli, Kuan-Teh Jeang

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BETA
NMR

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