Abstract
The synthesis of a series of 6-(substituted-phenyl)-1,2,4-triazolo[4,3-b]pyridazines (VIII) is reported. Some of these derivatives show activity in tests predictive of anxiolytic activity [(a) protection against pentylenetetrazole-induced convulsions; (b) thirsty rat conflict procedure]. They also represent a new class of compound which inhibits [3H]diazepam binding. Structure--activity correlations, as well as the ability of structures VIII to inhibit [3H]diazepam binding (in vitro), are discussed.
Citations
May 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·K J FehskeW E Müller
Jul 1, 1987·Journal of Computer-aided Molecular Design·S TebibC G Wermuth
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·R A Shephard
Aug 1, 1994·Bioorganic & Medicinal Chemistry·J Karolak-WojciechowskaJ Plenkiewicz
Jan 1, 1983·Journal of Psychoactive Drugs·W Haefely
Jan 1, 1987·British Journal of Pharmacology·K BiziereC G Wermuth
Oct 22, 2016·ACS Chemical Biology·Martina RoosJonathan Hall
Jan 25, 2008·Archiv der Pharmazie·Ahmed H Shamroukh, Mohamed A Ali
Feb 12, 2019·Oncogene·Chong ChenYunping Luo
Nov 14, 2008·Archiv der Pharmazie·Li-Ping GuanZhe-Shan Quan
Oct 12, 2010·Organic & Biomolecular Chemistry·Ram Shankar UpadhayayaJyoti Chattopadhyaya
Mar 1, 1985·Archiv der Pharmazie·D BinderJ M Wildburger
Aug 10, 2006·Molecular Diversity·Martine SchmittJean-Jacques Bourguignon
Jan 18, 2019·Cancer Immunology Research·Yanlian ChenYong Zhao
Jan 29, 2021·Neuro-oncology Advances·Mohit JainAru Narendran
Feb 9, 2019·Bioorganic Chemistry· MamtaGarima Sumran
Dec 21, 2016·ACS Medicinal Chemistry Letters·Qile XuWeige Zhang
Jul 31, 1998·Journal of Medicinal Chemistry·P JonesB R Leyland-Jones
Sep 14, 2002·The Journal of Organic Chemistry·Vyacheslav Ya SosnovskikhIvan I Vorontsov