PMID: 6113284May 1, 1981Paper

Synthesis and anxiolytic activity of 6-(substituted-phenyl)-1,2,4-triazolo[4,3-b]pyridazines

Journal of Medicinal Chemistry
J D AlbrightE N Greenblatt

Abstract

The synthesis of a series of 6-(substituted-phenyl)-1,2,4-triazolo[4,3-b]pyridazines (VIII) is reported. Some of these derivatives show activity in tests predictive of anxiolytic activity [(a) protection against pentylenetetrazole-induced convulsions; (b) thirsty rat conflict procedure]. They also represent a new class of compound which inhibits [3H]diazepam binding. Structure--activity correlations, as well as the ability of structures VIII to inhibit [3H]diazepam binding (in vitro), are discussed.

Citations

May 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·K J FehskeW E Müller
Jul 1, 1987·Journal of Computer-aided Molecular Design·S TebibC G Wermuth
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·R A Shephard
Jan 1, 1983·Journal of Psychoactive Drugs·W Haefely
Oct 22, 2016·ACS Chemical Biology·Martina RoosJonathan Hall
Jan 25, 2008·Archiv der Pharmazie·Ahmed H Shamroukh, Mohamed A Ali
Nov 14, 2008·Archiv der Pharmazie·Li-Ping GuanZhe-Shan Quan
Oct 12, 2010·Organic & Biomolecular Chemistry·Ram Shankar UpadhayayaJyoti Chattopadhyaya
Aug 10, 2006·Molecular Diversity·Martine SchmittJean-Jacques Bourguignon
Jan 18, 2019·Cancer Immunology Research·Yanlian ChenYong Zhao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.