Synthesis and application of fluorescein- and biotin-labeled molecular probes for the chemokine receptor CXCR4

Chembiochem : a European Journal of Chemical Biology
S OishiNobutaka Fujii

Abstract

The design, synthesis, and bioevaluation of fluorescence- and biotin-labeled CXCR4 antagonists are described. The modification of D-Lys8 at an epsilon-amino group in the peptide antagonist Ac-TZ14011 derived from polyphemusin II had no significant influence on the potent binding of the peptide to the CXCR4 receptor. The application of the labeled peptides in flow cytometry and confocal microscopy studies demonstrated the selectivity of their binding to the CXCR4 receptor, but not to CXCR7, which was recently reported to be another receptor for stromal cell-derived factor 1 (SDF-1)/CXCL12.

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Citations

Jul 8, 2011·Clinical & Experimental Metastasis·Manuela MeinckeRolf Mentlein
Apr 13, 2011·Bioconjugate Chemistry·Joeri KuilFijs W B van Leeuwen
Mar 28, 2013·Chemical Reviews·Prakasam ThirumuruganKrzysztof Jozwiak
Nov 17, 2011·Molecular Pharmaceutics·Joeri KuilFijs W B van Leeuwen
Oct 20, 2010·The Journal of Biological Chemistry·Stéphanie GravelNikolaus Heveker
Feb 6, 2013·Theranostics·Ido D Weiss, Orit Jacobson
Feb 5, 2014·Bioorganic & Medicinal Chemistry Letters·Kohei SanoTakahiro Mukai
May 11, 2012·Future Medicinal Chemistry·Ryo MasudaNobutaka Fujii
Apr 21, 2012·Organic & Biomolecular Chemistry·Shinya Oishi, Nobutaka Fujii
Jun 30, 2012·Chemical Society Reviews·Joeri KuilFijs W B van Leeuwen
Oct 26, 2011·Biomaterials·Anton BunschotenFijs W B van Leeuwen
May 17, 2011·Current Opinion in Chemical Biology·Kelly A Daggett, Thomas P Sakmar
Dec 17, 2008·Seminars in Cancer Biology·Hyunsuk ShimNobutaka Fujii
Jul 9, 2011·Chembiochem : a European Journal of Chemical Biology·Joeri KuilFijs W B van Leeuwen
Oct 15, 2011·Chembiochem : a European Journal of Chemical Biology·James C KnightPeter G Edwards
Dec 30, 2009·International Journal of Cancer. Journal International Du Cancer·Koji NishizawaOsamu Ogawa
Jan 22, 2010·Organic & Biomolecular Chemistry·Tetsuo NarumiNobutaka Fujii
Sep 12, 2015·Journal of Neurophysiology·Chie UmataniYoshitaka Oka
Aug 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Siyu ZhuZiwei Huang
Oct 27, 2020·Journal of Leukocyte Biology·Gary D LukerJohann Zimmermann
Jul 2, 2014·Journal of Medicinal Chemistry·Zhao MaMinyong Li
Jun 9, 2011·ACS Medicinal Chemistry Letters·Eriko InokuchiNobutaka Fujii
Apr 12, 2019·Bioconjugate Chemistry·Maxwell M SakyiamahHirokazu Tamamura

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