PMID: 640771Feb 1, 1978Paper

Synthesis and beta-conformation of copolypeptides with alternating hydrophilic and hydrophobic residues

International Journal of Peptide and Protein Research
A Brack, A Caille

Abstract

Copolypeptides with alternating hydrophilic and hydrophobic residues were prepared, and their ability to form beta-structures in aqueous solutions was investigated by circular dichroism. Optically pure samples of poly (Lys-Leu-Lys-Leu) and poly (Leu-Glu-Leu-Glu), obtained via the 2-hydroxyphenyl esters, undergo a coil-to-beta transition in presence of salt. The beta-structures obtained under identical conditions with partially racemized samples of poly (Leu-Lys)Np and poly (Leu-Glu)Np, prepared by polycondensation of the corresponding dipeptide p-nitrophenyl esters, appear to be less regular. Non-alternating poly (Gly-Lys-Leu-Lys-Leu) does not form beta-structures in presence of NaCl as does alternating poly (Lys-Leu-Lys-Leu) indicating that the amino acid sequence can dramatically change the tendency to form beta-structures.

References

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S BrahmsA Brack
Jul 1, 1977·Biopolymers·H J GorenR M Epand
Apr 20, 1973·Biochimica Et Biophysica Acta·P N LewisH A Scheraga
Jan 15, 1974·Biochemistry·P Y Chou, G D Fasman
Apr 5, 1973·Journal of Molecular Biology·W B RipponA G Walton
Oct 1, 1969·Journal of Biochemistry·T Yagi
Oct 14, 1971·Journal of Molecular Biology·B Lotz, H D Keith

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Citations

May 1, 1979·International Journal of Peptide and Protein Research·K Okahashi, S Ikeda
Jan 1, 1987·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·A Brack
Dec 10, 2015·PloS One·Michael P FriedmannRoland Riek
Jan 18, 2018·Nature Communications·Saroj K RoutJason Greenwald
Mar 1, 1997·The Journal of Peptide Research : Official Journal of the American Peptide Society·M BertrandA Brack
Jan 1, 1990·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·A Brack, B Barbier
Jan 1, 1987·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·B Barbier, A Brack
Jul 12, 2012·Biopolymers·Charles J Bowerman, Bradley L Nilsson
Aug 29, 2009·Journal of the American Chemical Society·Frank VersluisAlexander Kros
Jun 1, 1996·Bioorganic & Medicinal Chemistry·C L Nesloney, J W Kelly
Jan 1, 1985·Journal of Cellular Biochemistry·D G Osterman, E T Kaiser
Sep 24, 2011·Journal of the American Chemical Society·Babak SaniiRonald N Zuckermann

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