PMID: 6108563Oct 1, 1980Paper

Synthesis and biological actions of prosomatostatin

Proceedings of the National Academy of Sciences of the United States of America
C A MeyersA V Schally

Abstract

The recently isolated 28-residue sequence of prosomatostatin, a putative somatostatin precursor from pig hypothalamus and intestine, was synthesized by solid-phase methodology, characterized, and tested in rats for its effects on the release of insulin, glucagon, growth hormone, and prolactin. The synthetic product strongly suppressed plasma levels of insulin, glucagon, and growth hormone, and it appeared to be more active in the pancreas than in the pituitary. It inhibited insulin release about 5 times more effectively than somatostatin on a weight basis. The prohormone also suppressed growth hormone and prolactin levels in vitro. A time-course experiment for the effect of prosomatostatin on growth hormone release in vivo showed a significant suppression of plasma growth hormone for at least 90 min.

References

Jan 24, 1977·Biochemical and Biophysical Research Communications·C MeyersF Labrie
Mar 1, 1977·Journal of Medicinal Chemistry·C H LiH H Loh
Feb 10, 1976·Biochemistry·A V SchallyD H Schlesinger
May 1, 1970·Tetrahedron Letters·L D Markley, L C Dorman
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A V SchallyL E Hood

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Citations

Apr 15, 1987·Experientia·H NagasawaH Namiki
Jul 15, 1987·Experientia·P C AndrewsJ E Dixon
Jan 1, 1988·Progress in Neuro-psychopharmacology & Biological Psychiatry·D R RubinowR M Post
Dec 15, 1983·The New England Journal of Medicine·S Reichlin
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S J KonturekA V Schally
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T W Redding, A V Schally
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T W Redding, A V Schally
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R Z CaiA V Schally
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R Z CaiA V Schally
Jan 1, 1994·European Journal of Clinical Investigation·P HildebrandC Beglinger
Apr 1, 1986·Gut·M R Lucey
Sep 1, 1989·The Journal of Clinical Investigation·D A D'AlessioJ W Ensinck
Oct 1, 1990·The American Journal of the Medical Sciences·N J Brown
Nov 1, 1983·Clinics in Endocrinology and Metabolism·A Gómez-Pan, M D Rodriguez-Arnao
Nov 1, 1983·Clinics in Endocrinology and Metabolism·J A Wass
Oct 30, 1986·Biochemical and Biophysical Research Communications·P NicolasP Cohen
Jan 1, 1987·General and Comparative Endocrinology·S Harvey, T R Hall
Jul 16, 1981·Biochemical and Biophysical Research Communications·W A MurphyD H Coy
Nov 19, 1981·Nature·C B Srikant, Y C Patel
Jan 1, 1982·CRC Critical Reviews in Biochemistry·T L BlundellS P Wood
Mar 1, 1993·Journal of Endocrinological Investigation·J M Rondeel, I M Jackson
Jun 1, 1988·Journal of Endocrinological Investigation·G DelitalaR Virdis
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·P C Andrews, J E Dixon

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