Synthesis and biological activity assays of some new N1-(flavon-7-yl)amidrazone derivatives and related congeners

European Journal of Medicinal Chemistry
Marwa N Abu-AishehMohammad S Mubarak

Abstract

A series of new N1-(flavon-7-yl)amidrazones incorporating N-piperazines and related congeners were synthesized by reacting the hydrazonoyl chloride derived from 7-aminoflavone and 7-amino-2-methylchromen-4-one with the appropriate piperazine. The chemical structures of the newly prepared compounds were confirmed by elemental analyses, (1)H NMR, (13)C NMR, and ESI-HRMS spectral data. The antitumor activity of these compounds was evaluated on breast cancer (MCF-7 and T47D) and Leukemic (K562) cell lines by a cell viability assay utilizing the tetrazolium dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). Although with varying degrees, a significant growth inhibitory and cytotoxic effect was observed on all three cancer cell lines. Among the compounds tested compounds, 5a, 15a, and 18b, were the most active against T47D cell line with IC(50) values of 1.42, 1.92, and 2.92 μM, respectively. By using other cancer cell lines and with further characterization of their biological mechanism of action, these compounds could prove to be useful candidates as anticancer drugs.

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Citations

Dec 3, 2014·Bioorganic & Medicinal Chemistry Letters·Eeda VenkateswararaoSang-Hun Jung
Apr 3, 2014·European Journal of Medicinal Chemistry·Rangappa S KeriR Geetha Balakrishna
Mar 13, 2014·Archiv der Pharmazie·Almeqdad Y HabashnehMutasem O Taha
Jun 27, 2013·Integrative Psychological & Behavioral Science·Mohamed M Helmy, Sabine Frerichs
Aug 25, 2020·Pharmaceutical Chemistry Journal·Noor Ul Amin MohsinUsman Saleem
Jun 30, 2015·Journal of Computational Chemistry·Stephen J Barigye, Matheus P Freitas
Jun 4, 2021·Journal of Enzyme Inhibition and Medicinal Chemistry·Run-Hui ZhangZhe-Shan Quan
Sep 15, 2021·Chemical Biology & Drug Design·Vaishali M PatilVijay Masand

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