Synthesis and biological activity of 4''-O-acyl derivatives of 14- and 15-membered macrolides linked to omega-quinolone-carboxylic unit

Bioorganic & Medicinal Chemistry
Maja Matanović SkugorSulejman Alihodžić

Abstract

The synthesis and antimicrobial activity of a new class of macrolide antibiotics which consist of a macrolide scaffold and a quinolone unit covalently connected by an appropriate linker are described. Optimization of several synthetic steps and structural properties of lead compound 26 are discussed. Promising antibacterial properties of this compound and some of its analogues are reported.

References

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Citations

Aug 27, 2013·Journal of Pharmaceutical and Biomedical Analysis·Dubravka GembarovskiNives Galić
Jan 18, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Gennady B LapaMaria N Preobrazhenskaya
Jun 30, 2016·Antimicrobial Agents and Chemotherapy·Hana Čipčić PaljetakVesna Eraković Haber
Jan 13, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vera L M Silva, Artur M S Silva
Oct 14, 2018·The Journal of Antibiotics·Anna N TevyashovaIlya A Osterman
Jul 7, 2019·European Journal of Medicinal Chemistry·Joanna FedorowiczAdyary Fallarero

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