PMID: 11902642Mar 21, 2002Paper

Synthesis and biological activity of some 4-substituted 1-[1-(2,3-dihydroxy-1-propoxy)methyl-1,2,3-triazol-(4 & 5)-ylmethyl]-1H-pyrazolo[3,4-d]pyrimidines

Il Farmaco
O Moukha-chafiqE De Clercq

Abstract

Cycloaddition of 7a, b with 6 gave, after separation and deprotection, two regioisomers 10a, b and 11a, b. The deprotected acyclic nucleoside 10a used as the precursor for the preparation of 4-amino (12), 4-methylamino (13), 4-benzylamino (14), 4-methoxy (15) and 4-hydroxy (16) analogues. All acyclic nucleosides were evaluated for their inhibitory effects against HIV-1(IIIB), HIV-2(ROD) in MT-4 cells, for their anti-tumor activity and for their inhibitory effects against Mycobacterium tuberculosis. No marked activity was found.

References

Aug 1, 1988·Journal of Virological Methods·R PauwelsE De Clercq
Aug 1, 1987·Antimicrobial Agents and Chemotherapy·M A JacobsonJ Mills
Feb 1, 1997·The Journal of Antimicrobial Chemotherapy·D ZakulaR C Goldman

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Citations

Dec 31, 2010·Archives of Pharmacal Research·Mohamed T Abdel-AalAhmed L Zein
Mar 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abdelaaziz OuahrouchHassan B Lazrek
Oct 18, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Frankline K Keter, James Darkwa
Jun 27, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Khalid A Khan, Hassan M Faidallah
Jul 30, 2014·Journal of Enzyme Inhibition and Medicinal Chemistry·Ibrahim F NassarAbdel-Sattar S Hamad Elgazwy
Nov 6, 2010·Bioorganic & Medicinal Chemistry Letters·Hanane ElayadiHassan B Lazrek
Dec 19, 2003·Nucleosides, Nucleotides & Nucleic Acids·M TourirteN A Almasoudi
Mar 1, 2010·Journal of Biological Dynamics·Antonella Lunelli

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