Synthesis and biological activity of some new 5'-O-acyl tiazofurin derivatives

European Journal of Medicinal Chemistry
Vjera PejanovićVelimir Popsavin

Abstract

Three new 5'-O-acyl tiazofurin derivatives 2-4 were synthesized and evaluated for their antiproliferative activity against different tumour cell lines as well as for their ability to induce apoptosis in C6 cells in vitro. Apart of the antitumour assays, the cell membrane permeation of 2-4 and their intracellular metabolism in C6 cells in vitro was also studied in order to evaluate their potential as possible tiazofurin bioisosteres or prodrugs.

References

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Dec 23, 2003·Toxicology Letters·Vesna Vranić-MandusićBogomir Dimitrijević
Feb 5, 2004·Bioorganic & Medicinal Chemistry·Freddy RivaultJean-Pierre Gesson

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Citations

May 20, 2009·Biotechnology Progress·Zhao-Yu Wang, Min-Hua Zong
Sep 25, 2017·Biotechnology and Bioengineering·Daniel A SánchezMaría L Ferreira
Jul 21, 2010·Chemistry : a European Journal·Alessandro D'UrsoRoberto Purrello

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis