PMID: 6983630Nov 1, 1982Paper

Synthesis and biological activity of vitamin D2 3 beta-glucosiduronate and vitamin D2 3 beta-sulfate: role of vitamin D2 conjugates in calcium homeostasis

Journal of Steroid Biochemistry
R KumarS Nagubandi

Abstract

To ascertain the physiologic function of vitamin D2 conjugates in calcium homeostasis, we synthesized vitamin D2 3 beta-glucosiduronate and vitamin D2 3 beta-sulfate in pure form and tested their biological activity in vitamin D deficient rats fed a low calcium diet. Vitamin D2 3 beta-glucosiduronate was active in promoting calcium transport in the intestine at a dose of 100 pmol per rat. It increased calcium mobilization from bone and soft tissue at a dose of 1000 pmol per rat. This conjugate was less active than equimolar doses of vitamin D2. These results demonstrate that vitamin D2 3 beta-glucosiduronate can be utilized by the rat as a source of vitamin D. In contrast, vitamin D2 3 beta-sulfate was biologically inert. It failed to increase calcium transport in the duodenum of vitamin D deficient rats except at the highest doses tested (greater than 100,000 pmol/rat). It was similarly ineffective in increasing calcium mobilization from bone and soft tissue. Our results lead us to conclude that vitamin D2 3 beta-glucosiduronate is probably utilized by the rat after hydrolysis to the free sterol; on the contrary, the sulfate is not biologically active except at the highest doses tested.

References

Jun 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·S B ArnaudV L Go
Mar 10, 1969·The Journal of Vitaminology·Y SahashiT Asano
Jun 1, 1969·The American Journal of Physiology·D L Martin, H F DeLuca
Dec 1, 1980·The Journal of Clinical Investigation·S NagubandiP S Tietz
Jan 1, 1980·Endocrine Reviews·R Kumar
Mar 1, 1981·Digestive Diseases and Sciences·R KumarJ M Londowski
Feb 1, 1980·The Journal of Clinical Investigation·R KumarJ M Londowski

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Citations

Apr 1, 1986·Digestive Diseases and Sciences·J E LedgerJ E Compston
Mar 1, 1987·Journal of Steroid Biochemistry·M Axelson
Apr 30, 1983·Lancet·D R Fraser
Sep 4, 2003·The Journal of Clinical Investigation·Theresa BerndtRajiv Kumar
Jan 1, 1986·Journal of the American College of Nutrition·M Gascon-Barré
Jun 1, 1984·Die Naturwissenschaften·B ZagalakH C Curtius
Jul 7, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Carmen J ReynoldsJesse P Goff

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