Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor

Bioorganic & Medicinal Chemistry Letters
Nan-Horng LinHing L Sham

Abstract

Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anti-cancer agents. Analogs of the potent FTI, 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole, were synthesized and tested in vitro for their inhibitory activities. The most promising compound identified from this series is analog 29 that possesses potent enzymatic and cellular activities.

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Citations

May 30, 2009·Journal of Computer-aided Molecular Design·Aihua XieRobert J Doerksen
May 4, 2011·The Journal of Organic Chemistry·Ilaria D'AcquaricaBruno Botta
May 24, 2014·Archiv der Pharmazie·Reshma J NevagiKishor S Jain

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