Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives

European Journal of Medicinal Chemistry
Yu LiZhong-Xing Jiang

Abstract

To improve the druggability of salinomycin, a 20-epi-amino-20-deoxysalinomycin derivatives library was synthesized with high efficacy from which a few salinomycin derivatives with high potency and selectivity were identified through comprehensive cytotoxicity assay, including a fluorine-19 magnetic resonance sensitive tool molecule. Using a K-ras cellular model, salinomycin and its derivatives showed different molecular mode of action from literature reports. These results would be valuable for developing salinomycin-based cancer therapy.

Citations

Feb 23, 2020·Chemistry : a European Journal·Antoine VersiniRaphaël Rodriguez
Jul 16, 2020·Biomolecules·Michał SulikMichał Antoszczak
Jul 22, 2021·Chemical Communications : Chem Comm·Tingjuan WuZhong-Xing Jiang
Jul 16, 2021·European Journal of Pharmacology·Dominika CzerwonkaAdam Huczyński

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