Synthesis and biological evaluation of new securinine analogues as potential anticancer agents

European Journal of Medicinal Chemistry
Marc PerezVirginie Ratovelomanana-Vidal

Abstract

A series of new securinine analogues was prepared by Heck reaction from readily accessible securinine and commercially available iodoarenes. The in vitro cytotoxicity of the prepared compounds was assayed against a panel of four cancer cell lines: A375, A549, HCT-116 and HL-60 showing promising growth inhibition with excellent IC50 values in the nanomolar range. The plasmatic stability of the most potent analogue was also investigated demonstrating that they might serve as valuable leads for the development of anticancer drugs.

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Citations

Apr 21, 2016·ACS Medicinal Chemistry Letters·Marc PerezVirginie Ratovelomanana-Vidal
Oct 21, 2016·ACS Chemical Neuroscience·Genyun TangWei-Min Chen
Sep 8, 2016·Organic Letters·Johan CornilJanine Cossy
Feb 13, 2020·Frontiers in Bioengineering and Biotechnology·Liang YuLin Gao

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