Abstract
Novel series of 3-O-arylalkylbenzamide and 3-O-arylalkyl-2,6-difluorobenzamide derivatives were synthesized and evaluated for their on-target activity and antibacterial activity. The results indicated that the 3-O-arylalkyl-2,6-difluorobenzamide derivatives possessed much better on-target activity and antibacterial activity than the 3-O-arylalkylbenzamide derivatives. Among them, 3-O-chlorobenzyl derivative 36 was the most effective in antibacterial activity (0.5, 4, and 8 μg/mL) against Bacillus subtilis ATCC9372, methicillin-resistant Staphylococcus aureus ATCC29213, and penicillin-resistant Staphylococcus aureus PR, while 3-O-methylbenzyl derivative 41 only exhibited the most potent activity (2 μg/mL) against Staphylococcus aureus ATCC25923.
References
Sep 22, 2005·The Journal of Biological Chemistry·Neil R StokesJeff Errington
Sep 29, 2007·Journal of Molecular Biology·María A OlivaJan Löwe
Apr 19, 2008·Science·Masaki OsawaHarold P Erickson
Dec 10, 2008·Bioorganic & Medicinal Chemistry Letters·Lloyd G CzaplewskiNeil R Stokes
Mar 10, 2010·The Journal of Biological Chemistry·José M AndreuAntonio J Martín-Galiano
Apr 30, 2010·Journal of Medicinal Chemistry·David J HaydonLloyd Czaplewski
Nov 4, 2011·ACS Chemical Biology·Claudia Schaffner-BarberoJosé M Andreu
May 29, 2012·ChemMedChem·Siti Ma, Shutao Ma
Sep 6, 2012·Acta Crystallographica. Section D, Biological Crystallography·Takashi MatsuiIsao Tanaka
Nov 2, 2012·Antimicrobial Agents and Chemotherapy·Neil R StokesDavid J Haydon
Nov 7, 2012·Bioorganic & Medicinal Chemistry·Cody KelleyEdmond J LaVoie
Jun 19, 2013·Bioorganic & Medicinal Chemistry Letters·Siti MaShutao Ma
Aug 13, 2013·Current Opinion in Microbiology·Peter Sass, Heike Brötz-Oesterhelt
Dec 18, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Keith A Rodvold, Kevin W McConeghy
Apr 5, 2014·Journal of Laboratory Physicians·Bansidhar TaraiDilip Kumar
Sep 26, 2014·Current Opinion in Pharmacology·Gian Maria RossoliniSimona Pollini
Dec 3, 2014·European Journal of Medicinal Chemistry·Giuseppe ChiodiniErmanno Valoti
Mar 31, 2015·ACS Medicinal Chemistry Letters·Gabriella M NepomucenoJared T Shaw
May 6, 2015·European Journal of Medicinal Chemistry·Xin LiShutao Ma
Citations
Jan 26, 2018·Journal of Receptor and Signal Transduction Research·Srilata BalluVijjulatha Manga
May 30, 2017·Frontiers in Microbiology·Ning SunKwok-Yin Wong
Dec 10, 2020·Antibiotics·Wern Chern ChaiHenrietta Venter
Apr 29, 2021·Journal of Medicinal Chemistry·Sonia HuecasJosé M Andreu
Jul 20, 2018·ACS Omega·Kin-Fai ChanKwok-Yin Wong
Sep 16, 2021·Archiv der Pharmazie·Alejandra M Peter VenturaMartin Schlitzer