Abstract
Tumor chemotherapy, which plays an important role in the clinical treatment of metastatic cancer, is limited by low selectivity and drug resistance in clinical application. In our study, we selected antimicrobial peptide BP100 as a lead peptide, designed, and synthesized a series of novel antineoplastic peptides through solid-phase synthesis. Among them, B4 and B8 showed excellent anticancer activity. As revealed by further investigations, these peptides could disrupt the cell membrane, trigger the cytochrome C release into cytoplasm, and ultimately lead to apoptosis. In addition, they also showed multidrug resistance-reversing effects by performing effective antitumor activity against multidrug-resistant cells. As a result, these peptides may possibly be regarded as a promising candidate for cancer treatment.
References
Jan 1, 1993·Annual Review of Biochemistry·M M Gottesman, I Pastan
Aug 15, 1993·The Biochemical Journal·A Zachowski
Apr 3, 1997·Biochimica Et Biophysica Acta·A I de KroonB de Kruijff
Nov 1, 1978·Analytical Biochemistry·C T ChangJ T Yang
Feb 13, 1999·The Journal of Biological Chemistry·X M SunG M Cohen
Aug 19, 2000·Science·H LiX Zhang
Jan 30, 2002·FEMS Microbiology Letters·Robert E W Hancock, Annett Rozek
Mar 5, 2003·Pharmacological Reviews·Michael R Yeaman, Nannette Y Yount
Sep 1, 2005·Molecular and Cellular Biochemistry·Izabela DobrzyńskaZbigniew Figaszewski
Sep 22, 2005·Cancer Chemotherapy and Pharmacology·Ryungsa KimKazuaki Tanabe
Jun 1, 2006·Biopolymers·Nannette Y YountMichael R Yeaman
Oct 13, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T Fojo, M Menefee
Dec 15, 2007·Biochimica Et Biophysica Acta·David W Hoskin, Ayyalusamy Ramamoorthy
Jul 30, 2008·Bioinformatics·Romain GautierGuillaume Drin
Jul 9, 2009·Chemical Reviews·Paul D W Eckford, Frances J Sharom
Feb 22, 2011·European Biophysics Journal : EBJ·Katrin Splith, Ines Neundorf
May 31, 2011·Behavioural Brain Research·Michelle Monje, Jörg Dietrich
Oct 20, 2011·Peptides·Wei ChenJing Han
Oct 25, 2011·Public Health·R BeagleholeR Magnusson
Feb 11, 2012·Journal of Medicinal Chemistry·Kin-Fai ChanTak Hang Chan
Sep 7, 2012·Cold Spring Harbor Perspectives in Biology·Michael W Gray
Apr 12, 2013·PloS One·Che WangDe-Jing Shang
Feb 1, 2014·Organic & Biomolecular Chemistry·Marta SolerMarta Planas
Apr 20, 2014·Biochimica Et Biophysica Acta·Mariana C ManziniIolanda M Cuccovia
Dec 3, 2014·European Journal of Medicinal Chemistry·Xin DengHai Qian
Jan 1, 2015·American Journal of Respiratory and Critical Care Medicine·Andrew LiPyng Lee
Dec 29, 2015·Medical Science Monitor Basic Research·Dabiao Liu
Citations
Aug 24, 2017·Amino Acids·Bo ZhangLiang Ge
Jan 15, 2021·Journal of Peptide Science : an Official Publication of the European Peptide Society·Cibele Nicolaski PedronVani Xavier Oliveira Junior
May 27, 2021·Nanoscale·Wenlu TuZhilin Yu
Oct 17, 2020·Amino Acids·Geraldine Duque-SalazarSergio Orduz