Synthesis and Biological Evaluation of Novel Carbazole Hybrids as Promising Antimicrobial Agents

Chemistry & Biodiversity
Mahamadhanif S ShaikhRajshekhar Karpoormath

Abstract

Two series of carbazole analogs of 8-methoxy-N-substituted-9H-carbazole-3-carboxamides (series 1) and carbazolyl substituted rhodanines (series 2) were synthesized through facile synthetic routes. All the final compounds from these two series were evaluated for their preliminary in vitro antifungal and antibacterial activity against four fungal (Candida albicans, Cryptococcus neoformans, Cryptococcus tropicalis and Aspergillus niger) and four bacterial (Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa) strains, respectively. Among the tested compounds, three compounds of series 1 displayed promising antifungal and antibacterial activity, especially against C. neoformans and S. aureus. In addition, one compound of series 1 displayed notable antimicrobial activity (MIC: 6.25 μg/mL) against clinical isolates of C. albicans and C. neoformans (MIC: 12.5 μg/mL). From the second series, four compounds exhibited significant antifungal and antibacterial activity, especially against C. neoformans and S. aureus. The most active compound of series 2 displayed a prominent antimicrobial activity against C. neoformans (MIC: 3.125 μg/mL) and S. aureus (MIC: 1.56 μg/mL), respectively.

References

Jun 20, 1998·Journal of Applied Microbiology·C M Mann, J L Markham
Nov 14, 2002·Chemical Reviews·Hans-Joachim Knölker, Kethiri R Reddy
Aug 4, 2006·Journal of Medicinal Chemistry·Khuloud TakrouriMorris Srebnik
Jul 16, 2008·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Chih-Cheng LaiPo-Ren Hsueh
Sep 10, 2008·European Journal of Medicinal Chemistry·Perumal RajakumarNarayanasamy Mathivanan
Dec 17, 2008·International Journal of Antimicrobial Agents·J J Castón-OsorioJ Torre-Cisneros
Dec 17, 2008·International Journal of Antimicrobial Agents·Manuel Cuenca-EstrellaJuan Luis Rodriguez-Tudela
Oct 24, 2017·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Mohamed O Ahmed, Keith E Baptiste
Feb 2, 2018·Chemical & Pharmaceutical Bulletin·Siyuan WuAtsushi Nishida
Oct 24, 2018·Infection and Drug Resistance·Bilal AslamZulqarnain Baloch
May 2, 2019·Frontiers in Medicine·Matteo BassettiDaniele Roberto Giacobbe
Jun 23, 2019·Bioorganic & Medicinal Chemistry Letters·Mahamadhanif S ShaikhRajshekhar Karpoormath

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