Synthesis and biological evaluation of water-soluble organogermanium

European Journal of Medicinal Chemistry
Sumi ChoiSeung Wook Ham

Abstract

Interferon (INF) is an effective drug in treating several human diseases. Ge-132, which is the most common and well-studied organic germanium, has been reported to induce INF-gamma and has undergone clinical trials with promising preclinical results. However, it has been reported that long-term ingestion or high doses of organic Ge-132 causes similar toxic effects as GeO(2) because Ge-132 can be easily contaminated with significant amounts of inorganic germanium during the preparation. In this study, we synthesized the water-soluble organogermanium compound (Ge-OH) without possible contamination with toxic inorganic germanium and showed that Ge-OH is a better INF-gamma inducer than Ge-132 by an animal study.

Citations

Nov 16, 2018·Journal of Biochemical and Molecular Toxicology·Tuğba Kul KöprülüOsman Çakmak
Apr 26, 2018·Mini Reviews in Medicinal Chemistry·Yang LiYunmei Liu
Oct 5, 2018·Journal of Agricultural and Food Chemistry·Liangliang ZhangMan Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.