Abstract
The development of novel biologically active organometallic compounds bearing an acetylsalicylic acid (ASA) substructure led to the synthesis of analogical Zeise-type salts that accordingly inhibit cyclooxygenase (COX) enzymes. In order to determine the influence of the length of the alkyl chain between the platinum(II) center and the ASA moiety, compounds with varying methylene groups (n = 1⁻4) were synthesized and characterized. For the propene derivative structural elucidation by X-ray crystallography was possible. Prior to evaluation of biological activity, the complexes were investigated regarding their stability in different media, such as water, physiological sodium chloride, and phosphate buffered saline. Therefore, an analytical method based on capillary electrophoresis was established. All of the compounds were tested for their COX inhibitory potential. In general, complexes with longer alkyl chains caused higher inhibition of COX enzymes and the inhibitory potential towards COX enzymes was enhanced when compared to Zeise's salt. The growth inhibitory effects of the synthesized substances were investigated in vitro against colon carcinoma (HT-29) and breast cancer (MCF-7) cells. The IC50 values of the new derivatives ...Continue Reading
References
May 23, 1998·Annual Review of Pharmacology and Toxicology·J R VaneR M Botting
Oct 2, 1998·Journal of Inorganic Biochemistry·S ShamsuddinA R Khokhar
Dec 26, 2001·Chemical Reviews·J Reedijk
Oct 9, 2002·The American Journal of Pathology·Glen KristiansenSteffen Hauptmann
Jun 5, 2003·Cancer·Carsten DenkertSteffen Hauptmann
Feb 13, 1965·Nature·B ROSENBERGT KRIGAS
Jan 22, 2005·Journal of Medicinal Chemistry·Ingo OttRonald Gust
Mar 16, 2005·Rapid Communications in Mass Spectrometry : RCM·Ren MiaoLonggen Zhu
Feb 23, 2007·Archiv der Pharmazie·Ingo Ott, Ronald Gust
Aug 29, 2009·Chemical Reviews·Alice V Klein, Trevor W Hambley
Sep 11, 2010·European Journal of Medicinal Chemistry·Gerhard RubnerRonald Gust
Sep 23, 2010·Journal of Medicinal Chemistry·Gerhard RubnerRonald Gust
Oct 11, 2011·Archiv der Pharmazie·Gerhard RubnerRonald Gust
Nov 1, 2011·Lancet·John BurnUNKNOWN CAPP2 Investigators
Jan 9, 2015·Acta Crystallographica. Section C, Structural Chemistry·George M Sheldrick
Jan 22, 2015·Angewandte Chemie·Sandra MeieranzRonald Gust
Feb 13, 2016·Chemical Reviews·Timothy C JohnstoneStephen J Lippard
Mar 5, 2016·JAMA Oncology·Yin CaoAndrew T Chan
Aug 30, 2016·European Journal of Medicinal Chemistry·Victoria ObermoserRonald Gust
Feb 16, 2017·Chemistry : a European Journal·Farhana AmanChristian G Hartinger
Apr 21, 2017·Drug Design, Development and Therapy·Umar NdagiMahmoud E Soliman
Nov 25, 2017·Chemical Society Reviews·Samuel M Meier-MenchesBernhard K Keppler
Citations
Jul 1, 2020·Chemistry : a European Journal·Gilian T ThomasJason Scott McIndoe
Feb 16, 2020·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Monika Cziferszky, Ronald Gust
Aug 29, 2021·Pharmaceuticals·Md Kamrul IslamYongmin Chang
Dec 12, 2021·Archiv der Pharmazie·Daniel BaeckerRonald Gust