Synthesis and biological evaluation of neopeltolide and analogs.

The Journal of Organic Chemistry
Yubo CuiPaul E Floreancig

Abstract

The synthesis of neopeltolide analogues that contain variations in the oxazole-containing side chain and in the macrolide core are reported along with the GI(50) values for these compounds against MCF-7, HCT-116, and p53 knockout HCT-116 cell lines. Although biological activity is sensitive to changes in the macrocycle and the side chain, several analogues displayed GI(50) values of <25 nM. Neopeltolide and several of the more potent analogues were significantly less potent against p53 knockout cells, suggesting that p53 plays an auxiliary role in the activity of these compounds.

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Citations

Jul 5, 2012·The Journal of Organic Chemistry·Mahesh K LakshmanJan Balzarini
Dec 18, 2015·The Journal of Organic Chemistry·Taylor P A HariChristopher N Boddy
Apr 2, 2015·Organic & Biomolecular Chemistry·Martin E Maier
Jul 2, 2019·Organic & Biomolecular Chemistry·Shota YanagiHaruhiko Fuwa
Oct 15, 2013·Organic & Biomolecular Chemistry·Arun K GhoshZachary L Dawson
May 7, 2013·Natural Product Reports·Zhong Jin
Oct 9, 2012·The Journal of Organic Chemistry·Sudhakar AtheSubhash Ghosh
Apr 21, 2012·Organic Letters·Sadagopan Raghavan, Pradip Kumar Samanta
Feb 23, 2019·Journal of Agricultural and Food Chemistry·Xiao-Lei ZhuGuang-Fu Yang

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