Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors

Bioorganic & Medicinal Chemistry Letters
Claudia MugnainiFederico Corelli

Abstract

S-Aryl-S-DABO derivatives, a novel subclass of S-DABO anti-HIV-1 agents, were synthesized via Ullmann type reaction starting from the corresponding 2-thiouracils by the aid of microwave irradiation. The results of their evaluation as inhibitors of RT are reported together with their antiviral activity in cellular assays.

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Citations

Oct 8, 2013·European Journal of Medicinal Chemistry·M S MohamedN M Ahmed
Aug 25, 2007·Bioorganic & Medicinal Chemistry Letters·Claudia MugnainiMaurizio Botta
Aug 23, 2019·The Journal of Organic Chemistry·Xing Liu, Zhi-Bing Dong

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