Synthesis and biological investigation of the β-thiolactone and β-lactam analogs of tetrahydrolipstatin

Organic & Biomolecular Chemistry
Sylvain AubryDavid Crich

Abstract

The synthesis of β-thiolactone and β-lactam analogs of tetrahydrolipstatin is described from a common late-stage β-lactone derivative. These analogs, and a cis-disubstituted β-lactone analog of tetrahydrolipstatin, were screened for activity against porcine pancreatic lipase and for inhibition of cell growth of a panel of four human cancer lines.

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Citations

Dec 4, 2012·Current Opinion in Urology·Ferenc G RickAndrew V Schally
Sep 8, 2018·Natural Product Reports·Serina L RobinsonLawrence P Wackett
Jul 11, 2020·Beilstein Journal of Organic Chemistry·Jiaxi Xu
Jul 4, 2012·Organic & Biomolecular Chemistry·Amandine NoelDavid Crich
Mar 10, 2020·Current Topics in Medicinal Chemistry·Xinfen Zhang, Yanshu Jia
Jan 31, 2021·Life Sciences·Ashwani Kumar, Shilpi Chauhan
Mar 16, 2018·ACS Medicinal Chemistry Letters·Xiaofan LiuGeorge A O'Doherty

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