Synthesis and biological screening of 2'-aryl/benzyl-2-aryl-4-methyl-4',5-bithiazolyls as possible anti-tubercular and antimicrobial agents

European Journal of Medicinal Chemistry
Yogita K AbhalePravin C Mhaske

Abstract

A series of 2'-aryl/benzyl-2-aryl-4-methyl-4',5-bithiazolyl derivatives, 25-64 were synthesized and evaluated for inhibitory activity against Mycobacterium smegmatis MC(2) 155 strain and antimicrobial activities against four pathogenic bacteria Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Proteus vulgaris. Among them, compounds 40, 49, 50, and 54 exhibited moderate to good inhibition on the growth of the bacteria Mycobacterium smegmatis at the concentration of 30 μM. Compounds 26, 40, 44, 54 and 56 exhibited moderate to good antibacterial activity. Compound 5-(2'-(4-fluorobenzyl)thiazol-4'-yl)-2-(4-fluorophenyl)-4-methyl-thiazole (54) exhibited both antitubercular as well as antimicrobial activity against all tested strains.

References

Feb 1, 1997·The Journal of Antimicrobial Chemotherapy·D ZakulaR C Goldman

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Citations

Jun 10, 2017·Medicinal Research Reviews·Vajinder KumarRahul Jain
Dec 5, 2016·Bioorganic & Medicinal Chemistry Letters·Mahendra B BhaleraoRamrao A Mane
Jan 29, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anca-Maria BorceaOvidiu Oniga

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