Synthesis and biotinylation of oligosaccharide fragments of mannosylated and 5-deoxy-5-methylthio-xylofuranosylated lipoarabinomannan from Mycobacterium tuberculosis

Carbohydrate Research
Pintu Kumar Mandal, Pratik Rajesh Chheda

Abstract

The attachment of biotin to a molecule provides a powerful tool in biology. Here, we report an efficient synthesis and biotinylation of mannosylated and 5-deoxy-5-methylthio-xylofuranosylated Lipoarabinomannan from Mycobacterium tuberculosis. Preparation of the oligosaccharides involved the sequential addition of thioglycoside donors with arabinofuranosyl-containing acceptors. Methylthio group was introduced near the end of the synthesis.

References

Oct 9, 2002·Microbiology·Pascal LudwiczakGermain Puzo
Jul 11, 2009·Chembiochem : a European Journal of Chemical Biology·Michele R Richards, Todd L Lowary

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Citations

Jun 14, 2018·The Journal of Organic Chemistry·Li ZhangTodd L Lowary

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