PMID: 11836119Feb 12, 2002Paper

Synthesis and capillary electrophoretic analysis of enantiomerically enriched reference standards of MDMA and its main metabolites

Bioorganic & Medicinal Chemistry
Nieves PizarroJesús Joglar

Abstract

Enantiomerically-enriched (S)-3,4-methylenedioxymethamphetamine (MDMA) and its main metabolites (S)-4-hydroxy-3-methoxymethamphetamine (HMMA) and (S)-3,4-dihydroxymethamphetamine (HHMA) were prepared for unequivocal identification of the differential enantioselective metabolism of these compounds as well as for its application in the analysis of biological samples. Capillary electrophoresis with cyclodextrin derivatives and a chemical correlation of (S)-MDMA, (S)-HMMA and (S)-HHMA has been performed to assign the absolute stereochemistry of major isomers in analytical standards enriched with such enantiomers.

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Citations

Jun 5, 2013·Journal of Analytical Toxicology·Bardia JamaliMohammad-Reza Rouini
Jul 28, 2016·Free Radical Biology & Medicine·G TaghizadehM Sharifzadeh
Jan 7, 2005·The Journal of Pharmacology and Experimental Therapeutics·Douglas C JonesTerrence J Monks
Feb 6, 2003·Rapid Communications in Mass Spectrometry : RCM·Nieves PizarroRafael de la Torre
Jun 30, 2017·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Sanaz JamshidfarMohammadreza Rouini

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