Synthesis and characterisation of mucoadhesive thiolated polyallylamine

International Journal of Pharmaceutics
Sarah DugganOrla O' Donovan

Abstract

The thiolation of polyallylamine (PAAm) for use in mucoadhesive drug delivery has been achieved. PAAm was reacted with different ratios of Traut's reagent, yielding products with thiol contents ranging from 134-487μmol/g. Full mucoadhesive characterisation of the thiolated PAAm samples was conducted using swelling studies, mucoadhesive testing on porcine intestinal tissue and rheology. Both swelling and cohesive properties of the thiolated PAAm products were vastly improved in comparison to an unmodified PAAm control. The swelling abilities of the thiolated samples were high and the degree of thiolation of the products affected the initial rate of swelling. High levels of mucoadhesion were demonstrated by the thiolated PAAm samples, with adhesion times of greater than 24h measured for all three samples and, thus, thiol content did not appear to influence mucoadhesion. Rheological studies of the thiolated PAAm samples showed an increase in G' and G″ values upon the addition of a mucin solution which was not observed in the unmodified control, again highlighting the mucoadhesive interactions between these thiolated polymers and mucin. The synthesis of thiolated PAAm by reaction with Traut's reagent and resulting mucoadhesive prop...Continue Reading

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Citations

Mar 15, 2016·International Journal of Pharmaceutics·Claudia MenzelAndreas Bernkop-Schnürch
Sep 2, 2016·Drug Development and Industrial Pharmacy·Julia Anita GrießingerAndreas Bernkop-Schnürch
Nov 24, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Gintare LeonaviciuteAndreas Bernkop-Schnürch
Jan 15, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sarah DugganEleanor Owens
Mar 10, 2017·Drug Development and Industrial Pharmacy·Jéssica Bassi da SilvaMarcos Luciano Bruschi
Jul 5, 2017·Macromolecular Bioscience·Philipp SchattlingBrigitte Städler
Jul 31, 2019·Macromolecular Bioscience·Ruairí P Brannigan, Vitaliy V Khutoryanskiy
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Danielle M Beaupre, Richard G Weiss
Jul 27, 2018·Molecular Pharmaceutics·Aamir JalilAndreas Bernkop-Schnürch

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