Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors

Bioorganic & Medicinal Chemistry Letters
Aesop ChoChoung U Kim

Abstract

A series of 2'-C-methyl branched purine and pyrimidine C-nucleosides were prepared. Their anti-HCV activity and pharmacological properties were profiled, and compared with known 2'-C-Me N-nucleoside counterparts. In particular, 2'-C-Me 4-aza-7,9-dideazaadenosine C-nucleoside (2) was found to have potent and selective anti-HCV activity in vitro as well as a favorable pharmacokinetic profile and in vivo potential for enhanced potency over the corresponding N-nucleoside.

References

Aug 24, 2011·Antiviral Chemistry & Chemotherapy·Michael J Sofia
Dec 23, 2011·Seminars in Liver Disease·Marie-Louise Vachon, Douglas T Dieterich
Jan 18, 2012·Journal of Viral Hepatitis·B Kronenberger, S Zeuzem

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Citations

Apr 25, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohamed M El SadekGalila A Yacout
Sep 24, 2015·Nucleosides, Nucleotides & Nucleic Acids·Thorsten A KirschbergChoung U Kim
Oct 30, 2015·Journal of Medicinal Chemistry·Erik De Clercq
Jan 15, 2017·Magnetic Resonance in Chemistry : MRC·Rubria Marlen Martínez-CasaresLiliana Hernández Vázquez
Dec 1, 2017·Nucleosides, Nucleotides & Nucleic Acids·Rubria Marlen Martínez-CasaresAlberto López-Luna
Oct 28, 2014·Angewandte Chemie·Gabor ButoraIan W Davies
May 3, 2018·Beilstein Journal of Organic Chemistry·Kartik Temburnikar, Katherine L Seley-Radtke
Jan 2, 2021·European Journal of Medicinal Chemistry·Jakob BoutonSerge Van Calenbergh
Dec 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Konstantinos F MavreasThanasis Gimisis
Jun 20, 2014·ACS Medicinal Chemistry Letters·Alistair G DraffanSimon P Tucker

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