Synthesis and characterization of a novel antioxidant RS4 by esterifying carboxymethyl sweetpotato starch with quercetin

Carbohydrate Polymers
Xia LvGuohua Zhao

Abstract

Quercetin is grafted to carboxymethyl sweetpotato starch (CMSS) by esterification. Upon esterification, the water solubility of CMSS decreases and the CMSS-quercetin conjugates (CMSS-Q) are yellowish. FT-IR and 1H NMR indicated the covalent attachment of quercetin to CMSS. Thermogravimetry revealed the superior thermal stability of CMSS-Q over CMSS and native sweetpotato starch (NSS). The in vitro digestibility assays showed that CMSS is highly resistant to digestion while the quercetin graft with degree of substitution (DS) above 0.074 slightly increased its digestibility. The quercetin graft imparted CMSS with strong antioxidant activity and enhanced its thermal stability, which increased with quercetin DS. In vitro cyotoxicity assessment revealed that CMSS-Q is as safe as CMSS and NSS. This study showed that CMSS-Q is a novel antioxidant-resistant starch in RS4 form.

References

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Aug 11, 2007·International Journal of Pharmaceutics·Tzu-Hui WuThau-Ming Cham
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Dec 12, 2012·Carbohydrate Polymers·Ji Sheng YangWen He
Jul 6, 2014·International Journal of Biological Macromolecules·Weili Zhu, Zhanjun Zhang

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Citations

Apr 10, 2019·Current Medicinal Chemistry·Iolanda Francolini, Antonella Piozzi
Jan 23, 2021·International Journal of Biological Macromolecules·Huixia HuJun Liu
May 19, 2021·International Journal of Biological Macromolecules·Linqi YunJianbin Li

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