Synthesis and Characterization of a Novel Heterocyclic Schiff Base and Development of a Fluorescent Sensor for Vitamin B12.

Journal of Fluorescence
Savitha Devaswamparambil PradeepPuzhavoorparambil V Mohanan

Abstract

A heterocyclic Schiff base (MPDPI)was synthesized by the condensation reaction of 1-phenylisatin with 4,5-dimethylphenylene diamine. It was characterized by using spectroscopic methods including UV visible, Infrared, 1H-NMR, 13C-NMR and mass spectrometry. It acts as the fluorescent probe for the detection of Vitamin B12 (Vit.B12) which shows high selectivity over other species via dynamic quenching mechanism. It is also highly sensitive towards Vit.B12 with a detection limit of [Formula: see text]M and showed a linear concentration ranging from [Formula: see text] to [Formula: see text]. Effect of other coexisting species was also studied. The satisfactory results were also obtained in real samples.Since, there are only few reports on Vit.B12, development of selective fluorescent probes for Vit.B12 would be worthwhile.

References

Sep 1, 1995·Baillière's Clinical Haematology·D G Savage, J Lindenbaum
Aug 22, 1997·Journal of Chromatography. a·S Albalá-HurtadoA Mariné-Font
Mar 3, 2001·Fresenius' Journal of Analytical Chemistry·H B Li, F Chen
Dec 31, 2003·Analytical Chemistry·Peter TomcikRichard G Compton
Apr 6, 2005·Bioorganic & Medicinal Chemistry·Idan ChiyanzuKelly Chibale
Sep 27, 2005·Bioorganic & Medicinal Chemistry·Abd El-Galil E AmrMohamed M Abdalla
Aug 19, 2006·Journal of Alzheimer's Disease : JAD·Martha Clare MorrisChristine C Tangney
Jan 12, 2010·European Journal of Medicinal Chemistry·Aldo AndreaniEmanuela Greco
Jul 23, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·E Vaishnavi, R Renganathan
Oct 16, 2013·Luminescence : the Journal of Biological and Chemical Luminescence·Zhuo Bin ShangWei Jun Jin
Aug 16, 2014·Physical Chemistry Chemical Physics : PCCP·Mritunjoy MaityNakul C Maiti
May 6, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Pramod K SharmaVirinder S Parmar
Sep 19, 2016·Journal of Fluorescence·Unni SivasankaranKrishnapillai Girish Kumar
Dec 20, 2017·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Longhua DingJinghua Yu
Dec 12, 2018·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Yingping LiZhengjun Cheng
Feb 8, 2019·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Sanu K AnandK Girish Kumar
Jun 30, 2019·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Unni Sivasankaran, Krishnapillai Girish Kumar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.