Synthesis and characterization of a tetracycline-platinum (II) complex active against resistant bacteria

Journal of Inorganic Biochemistry
Edmar Chartone-SouzaE C Pereira-Maia

Abstract

A tetracycline-platinum(II) complex, [PtCl2(C22H24N2O8)], was synthesized and characterized by elemental analysis, conductivity and thermogravimetric analyses, and infrared spectroscopy. The interaction of tetracycline (Tc) with platinum(II) ions was also studied in aqueous solution by 1H NMR and circular dichroism spectroscopies. Tetracycline forms a 1:1 complex with platinum via the oxygen of the hydroxyl group at the A ring and that of the amide group. The complex is as efficient as tetracycline in inhibiting the growth of two Escherichia coli sensitive bacterial strains and six times more potent against E. coli HB101/pBR322, a bacterial strain resistant to tetracycline. This finding is very important because the use of tetracycline to treat bacterial infections has declined due to the emergence of resistant organisms.

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Citations

Oct 19, 2006·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mehmet TümerAkif Bulut
Oct 23, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Michael Lee BranhamPatrick Masina
Oct 22, 2016·Critical Reviews in Analytical Chemistry·Rúbia Adrieli SversutHérida Regina Nunes Salgado
Oct 18, 2005·Journal of Inorganic Biochemistry·Wendell GuerraElene C Pereira-Maia
Oct 31, 2008·Chemistry & Biodiversity·Flávia C S de PaulaElene C Pereira-Maia

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